Mitochondrial morphology shapes differentiation
Mitochondrial fission regulates the development of Drosophila egg chambers, Mitra et al. reveal.Fusion and fission proteins shape mitochondria into either long, interconnected tubules or…
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Protrusion drives osteoclast fusion
Oikawa et al. describe how the adaptor protein Tks5 promotes the formation of invasive podosomes in order to induce osteoclast cell fusion.As precursor cells…
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Cannabinoids suppress pain via α3 GlyR
Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an important target for nociceptive regulation at the spinal level. However, little is known…
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Antigen uptake and presentation in the lung
Asthma pathogenesis is focused around conducting airways. The reasons for this focus have been unclear because it has not been possible to track the…
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GSH/Trx control of H2O2 emission from mitochondria
The net emission of hydrogen peroxide (H2O2) from mitochondria results from the balance between reactive oxygen species (ROS) continuously generated…
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mPTP activation by inorganic polyphosphate
Mitochondrial dysfunction caused by excessive Ca2+ accumulation is a major contributor to cardiac cell and tissue damage during myocardial infarction and ischemia–reperfusion…
Podcasts
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biobytes: April 30, 2012
In the April 30th edition of biobytes, Arthur de Jong (VU University, Amsterdam, The Netherlands) describes how presynaptic strength is determined by dendritic position...(more)
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biosights: May 14, 2012
Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how cells move through three-dimensional environments is less well understood. Petrie et al. reveal that, depending on the strength of intracellular RhoA signaling... (more)
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