Unfinished basement membrane spurs developmental disorder
The integrin-binding protein QBRICK holds another integrin ligand in position, Kiyozumi et al. show, suggesting how defects in QBRICK lead to a rare developmental disorder.
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Recycling endosomes feed autophagy
By identifying a protein that hampers membrane trafficking within the cell, Longatti et al. provide evidence that recycling endosomes supply membrane to growing autophagosomes.When…
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Zinc finger zDC defines classical dendritic cells
Classical dendritic cells (cDCs), monocytes, and plasmacytoid DCs (pDCs) arise from a common bone marrow precursor (macrophage and DC progenitors [MDPs]) and express many…
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Neutrophil–pericyte interactions in vivo
Neutrophil transmigration through venular walls that are composed of endothelial cells (ECs), pericytes, and the venular basement membrane is a key component of innate…
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GSH/Trx control of H2O2 emission from mitochondria
The net emission of hydrogen peroxide (H2O2) from mitochondria results from the balance between reactive oxygen species (ROS) continuously generated…
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mPTP activation by inorganic polyphosphate
Mitochondrial dysfunction caused by excessive Ca2+ accumulation is a major contributor to cardiac cell and tissue damage during myocardial infarction and ischemia–reperfusion…
Podcasts
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biobytes: April 30, 2012
In the April 30th edition of biobytes, Arthur de Jong (VU University, Amsterdam, The Netherlands) describes how presynaptic strength is determined by dendritic position...(more)
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biosights: May 14, 2012
Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how cells move through three-dimensional environments is less well understood. Petrie et al. reveal that, depending on the strength of intracellular RhoA signaling... (more)
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