Myelinated axons need a 4.1G connection
Ivanovic et al. report that a glial cytoskeletal adaptor protein organizes the membranes of Schwann cells and the axons they ensheath.The speed of myelinated…
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Focal adhesions degrade the ECM
Wang and McNiven reveal how a matrix metalloproteinase (MMP) is recruited to focal adhesions, where it degrades the extracellular matrix (ECM) to promote tumor cell…
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SLP-76/ADAP regulates neutrophil recruitment
Neutrophils trigger inflammation-induced acute kidney injury (AKI), a frequent and potentially lethal occurrence in humans. Molecular mechanisms underlying neutrophil recruitment to sites of inflammation…
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FoxO1 in Ikaros splicing and Ig rearrangement
Somatic rearrangement of immunoglobulin (Ig) genes is a key step during B cell development. Using pro–B cells lacking the phosphatase Pten (phosphatase…
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Apical K channels in parotid cells
Ca2+ activation of Cl and K channels is a key event underlying stimulated fluid secretion from parotid salivary glands. Cl channels are…
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Kir1.1 selectivity and saturation
We investigated the features of the inward-rectifier K channel Kir1.1 (ROMK) that underlie the saturation of currents through these channels as a function of…
Podcasts
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biobytes: January 9, 2012
In the January 9th edition of biobytes, Hugo Bellen and Nikolaos Giagtzoglou (Baylor College of Medicine, Houston, TX) describe how ligand recycling regulates Notch signaling...(more)
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biosights: January 23, 2012
T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they invade through tissues. Gilden et al. reveal that septins function by assembling on membrane blebs to retract them back into shape.... (more)
» View all biosights
